Publications
(11) Samelson, A. J.; Ariqat, N.; McKetney, J.; Rohanitazangi, G.; Parra Bravo, C.; Bose, R.; Travaglini, K. J.; Lam, V. L.; Goodness, D.; Dixon, G.; Marzette, E.; Jin, J.; Tian, R.; Tse, E.; Abskharon, R.; Pan, H.; Carroll, E. C.; Lawrence, R. E.; Gestwicki, J. E.; Eisenberg, D.; Kanaan, N. M.; Southworth, D. R.; Gross, J. D.; Gan, L.; Swaney, D. L.; Kampmann, M. CRISPR Screens in iPSC-Derived Neurons Reveal Principles of Tau Proteostasis. Cell. 2026. https://doi.org/10.1016/j.cell.2025.12.038
(10) Charvat, A. F.; Mason-Chalmers, K.; Grabinska-Rogala, A.; Shivakumar, S.; Gale-Day, Z.; Wu, T.; Millbern, Z.; Grimm, J.; Carroll, E. C.; Nilsson, P.; Lavis, L.; Vinueza, N. R.; Gestwicki, J. E. Aurora 2.0: A Fluorogenic Dye Library for Expanding the Capability of Protein-Adaptive Differential Scanning Fluorimetry (paDSF). SLAS Discov. 2025, 100259. https://doi.org/10.1016/j.slasd.2025.100259.
(9) Carroll EC, Yang HE, Jones JG, Oehler A, Charvat, AF, Montgomery, KM, Yung A, Millbern Z, Vinueza NR, DeGrado, WF, Mordes DA, Condello C, Gestwicki JE. High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs. Nature Chemistry. 2025. https://doi.org/10.1038/s41557-025-01889-7
(8) Hur, Y.; Huynh, J.; Leong, E.; Dosanjh, R.; Charvat, A. F.; Vu, M. H.; Alam, Z.; Lee, Y. T.; Cabreros, C. C.; Carroll, E. C.; Hura, G. L.; Wang, N. The Differing Effects of a Dual Acting Regulator on SIRT1. Front. Mol. Biosci. 2023, 10 (1260489). https://doi.org/10.3389/fmolb.2023.1260489.
(7) Callahan, M.; Hodul, M.; Carroll, E. C.; Ravalin, M.; Nadel, C. M.; de Silva, A.; Cupo, A.; McDermott, L.; Nix, J.; Page, R.; Kao, A. W.; Gestwicki, J. E. Interaction with the Membrane-Anchored Protein CHIC2 Constrains the Ubiquitin Ligase Activity of CHIP. bioRxiv 2023.
(6) Wu, A. T.; Yu, J. C.; Suresh, A.; Gale-day, Z. J.; Alteen, M. G.; Woo, A. S.; Millbern, Z.; Johnson, O. T.; Carroll, E. C.; Partch, C. L.; Fourches, D.; Vinueza, N. R.; Vocadlo, D. J.; Gestwicki, J. E. Conformationally Responsive Dyes Enable Protein-Adaptive Differential Scanning Fluorimetry. bioRxiv 2023.
Published in Nat. Biotechnol. 2024
(5) Montgomery, K. M.; Carroll, E. C.; Thwin, A.; Hodges, P.; Southworth, D. R.; Gestwicki, J. E. The Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States Authors: J. Am. Chem. Soc. 2023, 145 (7).
(4) Johnson, O. T.*; Nadel, C. M.*; Carroll, E. C.; Arhar, T.; Gestwicki, J. E. Two Distinct Classes of Co-Chaperones Compete for the EEVD Motif in Heat Shock Protein 70 (Hsp70) to Tune Its Chaperone Activities. J. Biol. Chem. 2022, 298 (3), 101697. https://doi.org/10.1016/j.jbc.2022.101697.
(3) Carroll, E. C.; Marqusee, S. Site-Specific Ubiquitination : Deconstructing the Degradation Tag. Curr. Opin. Struct. Biol. 2022, 73, 102345. https://doi.org/10.1016/j.sbi.2022.102345.
(2) Carroll, E. C.*; Latorraca, N. R.*; Lindner, J. M.; Maguire, B. C.; Jeff, G. Mechanistic Basis for Ubiquitin Modulation of a Protein Energy Landscape. bioRxiv 2020.
(1) Carroll, E. C.; Greene, E. R.; Martin, A.; Marqusee, S. Site-Specific Ubiquitination Affects Protein Energetics and Proteasomal Degradation. Nat. Chem. Biol. 2020. https://doi.org/10.1038/s41589-020-0556-3.